Studies on a model of bitter peptides including arginine, proline and phenylalanine residues. III. Bitterness of diastereomers of a hexapeptide (Arg-Arg-Pro-Pro-Phe-Phe) containing D-phenylalanine in place of L-phenylalanine.
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Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin.
Investigations determined the mechanism(s) by which Arg-Pro-Pro-Gly-Phe (RPPGF) inhibits thrombin-induced platelet activation. High concentrations of RPPGF inhibit thrombin-induced coagulant activity. RPPGF binds to the active site of thrombin by forming a parallel beta-strand with Ser214-Gly216 and interacts with His57, Asp189, and Ser195 of the catalytic triad. RPPGF competitively inhibits al...
متن کاملNeuropeptides Gly-Asp-Pro-Phe-Leu-Arg-Phe-amide (GDPFLRFamide) and Ser-Asp-Pro-Phe-Leu-Arg-Phe-amide (SDPFLRFamide) Are Encoded by an Exon 3’ to Phe-Met-Arg-Phe- NH, (FMRFamide) in the Snail Lymnaea stagnalis
Biochemical analysis has shown the pond snail Lymnaea stagnalis to contain 2 main classes of Phe-Met-Arg-Phe-NH, (FMRFamide)-like neuropeptides: the tetrapeptides FMRFamide and Phe-Leu-Arg-Phe-NH, (FLRFamide), and the heptapeptides Gly-Asp-Pro-Phe-Leu-Arg-Phe-NH, (GDPFLRFamide) and Ser-Asp-Pro-Phe-Leu-Arg-Phe-NH, (SDPFFRFamide). By genomic mapping and DNA sequencing, we show here that the GDP/S...
متن کاملRational Design and Characterization of D-Phe-Pro-D-Arg-Derived Direct Thrombin Inhibitors
The tremendous social and economic impact of thrombotic disorders, together with the considerable risks associated to the currently available therapies, prompt for the development of more efficient and safer anticoagulants. Novel peptide-based thrombin inhibitors were identified using in silico structure-based design and further validated in vitro. The best candidate compounds contained both L-...
متن کاملThr - Asp - Glu - pro - Phe - - Ser - Gln - Lys - Gly - Arg - Met - Ser - Arg
Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providin...
متن کاملAsp - Glu - pro - Phe - - Ser - Gln - Lys - Gly - Arg - Met - Ser - Arg
Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providin...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1986
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.50.1785